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Apexbio Technology LLC BQU57 1637739-82-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A95035.1

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BQU57 (CAS 1637739-82-2) is a small-molecule inhibitor derived from RBC8 selectively targeting the GDP-bound form of the Ral GTPases BQU57 binds preferentially to RalB-GDP exhibiting measured dissociation constants (Kd) of approximately 7 7 M (ITC) and 4 7 M (SPR) In vitro assays using cell lines such as H2122 and H358 have shown suppression of Ral-dependent anchorage-independent colony formation at IC50 values of 2 0 M and 1 3 M respectively In mouse xenograft tumor models administration of BQU57 resulted in reduced activation of RalA and RalB without affecting Ras or RhoA signaling highlighting its utility as a tool compound for investigating Ral-driven tumor biology

Catalog No. 50-000-63362


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