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Medchemexpress LLC BRD0539 | 1403838-79-8 | 98.33% | 452.54 | 100 MG
Supplier: Medchemexpress LLC HY136251100MG
BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC50 of 22 μM in an in vitro DNA cleavage assay.
- Dose-dependently blocks the formation of the DNA-bound state.
- Impairs the perturbation induced by 4PAM DNA.
- Does not interfere with the SpCas9:gRNA interaction.
- Inhibits SpCas9 in the eGFP-disruption assay.
- Unable to inhibit FnCpf1.
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