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Medchemexpress LLC Brepocitinib | 1883299-62-4 | 99.97% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11270810MG

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Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. It also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.

  • Potently inhibits TYK2/JAK2 mediated IL-12/pSTAT4 and IL-23/pSTAT3.
  • Shows good potency against IL6/pStat1 in the CD3+ cellular subset.
  • Inhibits JAK1/JAK3 driven γ-common chain cytokines such as IL-15/pStat5 and IL-21/pSTAT3.
  • Reduces paw volume increase in a dose-dependent manner in vivo.
  • Store at 4°C, protect from light.

Catalog No. 50-004-38544


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