Medchemexpress LLC Brilanestrant | 1365888-06-7 | 99.9% | 25 MG

Supplier:  Medchemexpress LLC 25MGHY12864

Brilanestrant is an orally bioavailable selective estrogen receptor degrader (SERD) with an IC₅₀ of 0.7 nM. It demonstrates potency and efficacy in ER-α degradation and MCF-7 breast cancer cell viability assays, acting as a full transcriptional antagonist without agonism. It induces a distinct ERα conformation and does not exhibit tamoxifen-like ER agonism in MCF7 cells.

• Potent ER-α binder.
• Full transcriptional antagonist with no agonism.
• Effective in ER-α degradation and MCF-7 breast cancer cell viability assays.
• Induces a distinct ERα conformation and lacks tamoxifen-like ER agonism.
• Exhibits low clearance and good bioavailability across species.
• Demonstrates substantial tumor-growth inhibition in tamoxifen-sensitive MCF-7 xenograft models.

Catalog No. 50-003-42982