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Medchemexpress LLC BSJ-03-204 | 2349356-09-6 | 99.8% | 832.90 | 25 MG
Supplier: Medchemexpress LLC 25MGHY136250
BSJ-03-204 is a PROTAC that connects ligands for Cereblon and CDK. It is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1. This compound does not induce IKZF1/3 degradation and exhibits anti-cancer activity.
- Potent and selective CDK4/6 dual degrader
- Does not cause IKZF1/3 degradation
- Demonstrates anti-cancer activity
- Potent anti-proliferative effects on MCL cell lines
- Induces G1 arrest
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