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Apexbio Technology LLC BT2 34576-94-8 50mg
Supplier: Apexbio Technology LLC BA332950
BT2 (CAS 34576-94-8) is a small-molecule inhibitor of branched-chain -ketoacid dehydrogenase kinase (BCKDK) By binding to BCKDK BT2 induces conformational changes in the N-terminal domain promoting dissociation from the branched-chain -ketoacid dehydrogenase complex (BCKDC) BT2 suppresses BCKDK activity with an IC50 of 3 19 M and demonstrates selective inhibition as indicated by an IC50 of 59 M in relevant assays This compound serves as a valuable tool for investigating BCKDK-regulated metabolic pathways and the role of BCKDK in branched-chain amino acid metabolism
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