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Medchemexpress LLC Bumetanide | 28395-03-1 | 99.9% | 364.42 | 10 G
Supplier: Medchemexpress LLC HY1746810G
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
- Highly potent loop diuretic
- Na+-K+-Cl+ cotransporter (NKCC) blocker
- Selective NKCC1 inhibitor
- Inhibits NKCC2 with IC50 of 4.0 μM for hNKCC2A
- IC50 of 0.68 μM for hNKCC1A
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