Apexbio Technology LLC BVT 948 39674-97-0 5mg

Supplier:  Apexbio Technology LLC A45435

BVT 948 (CAS 39674-97-0) is a non-competitive cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with reported IC50 values ranging from 0 09 to 1 7 M PTPs are involved in the regulation of diverse intracellular signaling pathways In cellular studies BVT 948 suppresses the expression and secretion of matrix metalloproteinase-9 (MMP-9) in MCF-7 breast cancer cells thereby inhibiting cell invasion without affecting cell viability after 24 hours of exposure Mechanistic investigations indicate that BVT 948 impedes NF- B activation by blocking I B degradation and nuclear translocation of NF- B and this regulation of MMP-9 is independent of the MAPK pathway BVT 948 is utilized in research to investigate PTP-mediated signaling and cancer cell invasiveness

Catalog No. 50-000-94188