Medchemexpress LLC Bx795 | 702675-74-9 | 99.84% | 591.47 | 200 MG

Supplier:  Medchemexpress LLC 200MGHY10514

BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. It is also a potent and relatively specific inhibitor of TBK1 and IKKε, having IC50 values of 6 nM and 41 nM, respectively. BX795 works by blocking the phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and exhibits lower selectivity over PKA, PKC, c-Kit, and GSK3β, among others. Additionally, BX795 modulates autophagy.

• Effectively blocks PDK1 activity in PC-3 cells.
• Inhibits the phosphorylation of S6K1, Akt, PKCδ, and GSK3β.
• Potently inhibits tumor cell growth on plastic.
• Shows higher growth inhibition in soft agar.
• Blocks TBK1- and IKKε-mediated activation of IRF3 and the production of IFN-β.
• Demonstrates an inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion, and thromboxane generation in platelet physiological responses.

Catalog No. 50-003-66167