Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000352482

Medchemexpress LLC C004019 | 2417159-57-8 | 99.7% | 1035.29 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY138669100MG

Encompass_Preferred

C004019 is a BBB-penetrable, small-molecule PROTAC designed to target tau protein. It works by recruiting tau and E3 ligase simultaneously, promoting the ubiquitination and proteasome-dependent degradation of tau. This action has been shown to improve synaptic and cognitive functions in Alzheimer's disease (AD) mice, making it suitable for research in AD and tau protein-related diseases.

  • Does not significantly affect viability of HEK293 cells.
  • Inhibits expression of total tau and phosphorylated tau in HEK293-hTau and SH-SY5Y cells.
  • Reduces tau protein levels in the brains of wild-type and 3xTg-AD mice.
  • Promotes tau clearance and improves cognitive and synaptic functions in hTau and 3xTg-AD mice.
  • Ameliorates cognitive functions and dendritic plasticity.

Catalog No. 50-003-52482


May include imposed supplier surcharges.
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.