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Medchemexpress LLC C12-TLRa | 3067466-15-0 | C46H73N5O2 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY15387950MG

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C12-TLRa is an ionized adjuvant lipid that targets TLR7/8 receptors in endosomes. It enhances mRNA delivery as a structural component of LNPs and boosts innate immune responses, making it suitable for research, including SARS-CoV-2 mRNA vaccines. Internally, C12-TLRa LNP (10-40 ng per well) shows dose-dependent mRNA transfection in DC2.4 cells with ~75% encapsulation efficiency. In vivo, C12-TLRa-substituted LNPs (5 μg mRNA per mouse) enhance mRNA transfection at injection sites and inguinal lymph nodes in C57BL/6 mice, significantly increasing mature DCs.

  • Targets TLR7/8 receptors in endosomes
  • Enhances mRNA delivery as a structural component of LNPs
  • Boosts innate immune responses
  • Suitable for SARS-CoV-2 mRNA vaccine research
  • Dose-dependent mRNA transfection
  • Enhances mRNA transfection at injection sites and inguinal lymph nodes

Catalog No. 50-003-76090


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