AdipoGen CA771

Supplier:  AdipoGen AGCR10165M025

Chemical. CAS 2412270-22-3. Formula C16H12ClN3O. MW 297.7. CA77.1 is a novel selective chaperone-mediated autophagy CMA activator by increasing the expression of the lysosomal receptor for this pathway, LAMP2A, in lysosomes. Chaperone-mediated autophagy CMA, is a selective autophagy shown to degrade neurodegeneration-related proteins such as alpha-synuclein alpha-syn or tau. Loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome and proteotoxicity. Chemical upregulation of CMA has been shown to ameliorate pathology in AD experimental mouse models, reduce brain pathology and improve disease phenotype. CA77.1 is able to activate CMA in vitro and in vivo in contrary to its derivative AR7 which was not suitable for in vivo application. CA77.1 is able to activate CMA in vivo, and demonstrates brain penetrance and favorable pharmacokinetics.

Catalog No. 50-256-2349