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Apexbio Technology LLC Cabozantinib (XL184, BMS-907351) 849217-68-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A29775.1
Cabozantinib (XL184 BMS-907351 CAS 849217-68-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) notably VEGFR2 MET and RET with reported IC50 values of 0 035 nmol/L 1 3 nmol/L and 5 2 nmol/L respectively Acting by blocking downstream phosphorylation events cabozantinib disrupts RTK-mediated cell signaling pathways fundamental to cellular proliferation and differentiation In vitro studies utilizing RET-mutant TT cells showed dose-dependent inhibition of RET autophosphorylation (IC50 85 nmol/L) and reduced cellular proliferation In vivo experiments using TT-cell xenograft mouse models demonstrated tumor growth suppression and decreased serum calcitonin levels Cabozantinib serves as a valuable tool in oncology and RTK-related signaling research
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