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AdipoGen Cabozantinib
SDP

Supplier:  AdipoGen CDXC0755M050

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Chemical. CAS 849217-68-1. Formula C28H24FN3O5. MW 501.5. Cabozantinib is a potent multi-targeted receptor tyrosine kinase RTK inhibitor of endothelial growth factor receptor 2 VEGFR2 IC50=0.035nM, the hepatocyte growth factor receptor c-Met IC50=1.3nM, AXL IC50=7nM, fms like tyrosine kinase 3 FLT3 IC50=11.3nM, mast/stem cell growth factor KIT IC50=4.6nM, RET IC50=5.2nM, tyrosine-protein kinase receptor TIE-2 IC50=14.3nM and RON IC50=124nM. Cabozantinib reduces cell proliferation and vascular density. It also induces apoptosis and intratumoral hypoxia. Cabozantinib exhibits dose-related tumor growth inhibition, tumor regression, angiogenesis and/or metastasis inhibition in a broad range of preclinical tumor models.

Catalog No. 50-256-1340


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