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Apexbio Technology LLC Cabozantinib malate (XL184) 1140909-48-3 25mg
Supplier: Apexbio Technology LLC B140125
Cabozantinib malate (XL184 CAS 1140909-48-3) is a small-molecule inhibitor targeting multiple receptor tyrosine kinases notably MET and VEGFR2 with reported IC50 values of 1 3 nM and 0 035 nM respectively It also inhibits additional kinases including RET FLT3 KIT AXL and TEK In cellular assays Cabozantinib shows inhibition of phosphorylation in kinases MET VEGFR2 KIT FLT3 and AXL Moreover Cabozantinib suppresses HMVEC cell-tube formation (IC50 6 7 nM) and attenuates hepatocyte growth factor-induced tumor cell invasion and migration This compound has demonstrated antiproliferative activity in several cancer cell lines supporting its application in oncology research environments
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