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Apexbio Technology LLC Calpain Inhibitor I, ALLN(Synonyms: ALLN, N-Acetyl-Leu-Leu-Nle-CHO, Ac-LLnL-CHO, Calpeptin, MG101, CI-I), 10mM (in 1mL DMSO), CAS: 110044-82-1.
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Supplier:  Apexbio Technology LLC A26025.1

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Calpain Inhibitor I (ALLN CAS 110044-82-1) is a potent inhibitor of calpain I (Ki 190 nM) calpain II (Ki 220 nM) cathepsin B (Ki 150 nM) and cathepsin L (Ki 500 pM) It enhances TRAIL-mediated apoptosis in DLD1-TRAIL/R cells as indicated by pronounced activation and cleavage of caspase-8 and caspase-3 while minimally cytotoxic on its own In vivo studies in Sprague-Dawley rats demonstrate reduced ischemia-reperfusion injury markers including decreased neutrophil infiltration lipid peroxidation adhesion molecule expression and I B- degradation highlighting its potential in inflammation research

Catalog No. 50-000-60452


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