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Apexbio Technology LLC Capecitabine(Synonyms: Xeloda, Ro 09-1978, N4-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine), 5g, CAS: 154361-50-9.
Supplier: Apexbio Technology LLC A86475000
Capecitabine (CAS 154361-50-9) chemically defined as N4-pentyloxycarbonyl-5 -deoxy-5-fluorocytidine is an anticancer fluoropyrimidine prodrug that enzymatically converts into the cytotoxic agent 5-fluorouracil (5-FU) through sequential activation by enzymes predominantly expressed in tumors and liver tissues Mechanistically Capecitabine induces apoptosis via Fas-dependent pathways particularly in cells with elevated thymidine phosphorylase (TP) activity as observed in engineered LS174T colon cancer cell lines In mouse xenograft models of colon carcinoma and hepatocellular carcinoma Capecitabine administration reduced tumor growth metastasis and recurrence correlating to PD-ECGF expression These characteristics make Capecitabine relevant in preclinical oncology studies investigating chemotherapy selectivity and tumor-targeted drug delivery
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