Medchemexpress LLC Capivasertib | 1143532-39-1 | C21H25ClN6O2 | 200 MG

Supplier:  Medchemexpress LLC HY15431200MG

Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor, effectively inhibiting Akt1, Akt2, and Akt3 with high selectivity. This compound demonstrates in vitro inhibition of cancer cell proliferation, leading to apoptosis and G1 cell cycle arrest. In vivo studies confirm its good oral bioavailability, favorable pharmacokinetic properties, and significant ability to inhibit tumor growth in various human xenograft models. It is currently undergoing clinical evaluation.

• Potent pan-AKT kinase inhibitor
• Highly selective for Akt over other kinases
• Inhibits proliferation in diverse cancer cell lines
• Induces apoptosis and G1 cell cycle arrest
• Exhibits good oral bioavailability
• Effectively inhibits tumor growth in xenograft models
• Inhibits P70S6K, PKA, and ROCK2 activity
• Suppresses phosphorylation of AKT substrates
• Induces FOXO3a nuclear translocation

Catalog No. 50-003-76642