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Apexbio Technology LLC Carfilzomib (PR-171), 868540-17-4, MFCD11040997, 5 mg

Supplier: Apexbio Technology LLC A19335
MF: C40H57N5O7, MW: 719.91, Solubility: 36.0mg/mL in DMSO. An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
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