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Apexbio Technology LLC CARIPORIDE 159138-80-4 100mg
Supplier: Apexbio Technology LLC B5895100
Cariporide (CAS 159138-80-4) is a potent and selective inhibitor of the Na /H exchanger isoform 1 (NHE1) exhibiting IC50 values of 0 05 M for NHE1 3 M for NHE3 and 1000 M for NHE2 By targeting NHE1 cariporide modulates ionic homeostasis implicated in the pathogenesis of myocardial ischemia-reperfusion injury In vitro cariporide concentration-dependently inhibits amiloride-sensitive sodium influx in rabbit erythrocytes and reduces platelet swelling induced by cellular acidification In vivo studies have demonstrated that both intravenous and oral administration in anesthetized rats attenuates or prevents ventricular arrhythmias following coronary ligation Cariporide has been explored in clinical trials related to acute coronary syndromes and is a valuable tool for cardiovascular research involving NHE1 modulation
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