Apexbio Technology LLC Carmustine 154-93-8 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B34895.1

Carmustine (CAS 154-93-8) is a -chloro-nitrosourea nitrogen mustard compound utilized as an antitumor chemotherapeutic agent It exerts its effects primarily through alkylation of DNA and proteins leading to cross-linking and inhibition of cellular replication and function In research studies carmustine has been shown to attenuate N-acetyltransferase activities for substrates such as 2-aminofluorene and p-aminobenzoic acid in rat glial tumor models and to decrease the formation of DNA-2-aminofluorene adducts In vivo carmustine administration in rats impacts hepatic parameters including increased liver-to-weight ratio reduced bile flow and altered glutathione redox status accompanied by histological changes Carmustine is widely employed in oncology research to investigate mechanisms of cytotoxicity and drug-induced liver injury

Catalog No. 50-000-94325