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Medchemexpress LLC Casticin (Vitexicarpin) | 479-91-4 | 374.34 | 25 MG
Supplier: Medchemexpress LLC 25MGHYN0516
Casticin is a methoxylated flavonol isolated from *Vitex rotundifolia* with antimitotic and anti-inflammatory effects. It inhibits the activation of STAT3, a protein involved in cell growth and division.
- Inhibits proliferation of KB cells and LX2 cells.
- Induces apoptosis in L02 cells.
- Reduces viability of 786-O, YD-8, and HN-9 cells.
- Increases cleavage caspase-3 and PPAR.
- Diminishes levels of Bcl-xl, Bcl-2, IAP-1/-2, VEGF, MMP-9, and COX-2 proteins.
- Promotes apoptotic cell death in tumor cells.
- Enhances the effect of ionizing radiation in 786-O cells.
- Attenuates liver fibrosis induced by CCl4 or BDL in vivo.
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