ABclonal Technology Cation-independent M6PR IGF2R

Supplier:  ABclonal Technology A22421PM20UL

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate The binding sites for each ligand are located on different segments of the protein This receptor has various functions including in the intracellular trafficking of lysosomal enzymes the activation of transforming growth factor beta and the degradation of insulin-like growth factor 2 Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele however imprinting of the human gene may be polymorphic as only a minority of individuals showed biased expression from the maternal allele (PMID 8267611)

Catalog No. 50-000-06895