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Medchemexpress LLC Cay10603 | 1045792-66-2 | 99.8% | 446.50 | 1 G
Supplier: Medchemexpress LLC HY186131G
CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM. It also inhibits HDAC1, HDAC2, HDAC3, HDAC8, and HDAC10. This compound exhibits potent inhibitory activities against various pancreatic cancer cell lines and induces apoptosis in lung adenocarcinoma cells.
- Potent and selective HDAC6 inhibitor.
- Exhibits potent inhibitory activities against various pancreatic cancer cell lines (e.g., BxPC-3, HupT3, Mia Paca-2, Panc 04.03, SU.86.86, HMEC, HPDE6c7) with IC50s ranging from 0.1 to 1 μM.
- Inhibits HDAC6 deacetylase activity and suppresses the proliferation of lung adenocarcinoma cells.
- Induces apoptosis in lung adenocarcinoma cells.
- Synergizes with gefitinib to induce apoptosis in lung adenocarcinoma cell lines, partially by destabilizing EGFR and inactivating the EGFR pathway.
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