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TARGETMOL CHEMICALS INC CBL-B-IN-3 5MG
SDP

Supplier:  TARGETMOL CHEMICALS INC T637905MG

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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b a cyclic E3 ubiquitin protein ligase is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner and participates in the recruitment of p85 to CD28 and T cell antigen receptor (zeta) through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation. purity: 98%

Catalog No. 50-257-9401


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