Apexbio Technology LLC CC-115 1228013-15-7 25mg

Supplier:  Apexbio Technology LLC B611425

CC-115 (CAS 1228013-15-7) is a dual inhibitor targeting both mTOR and DNA-dependent protein kinase (DNA-PK) with reported IC50 values of 21 nM and 13 nM respectively mTOR is a critical component of the PI3K/AKT pathway while DNA-PK plays an essential role in DNA repair processes and genomic stability In vitro studies demonstrate that CC-115 inhibits CD40( ) IL-21-induced proliferation and can reverse CD40-mediated resistance to fludarabine and venetoclax in chronic lymphocytic leukemia (CLL) cells It also blocks BCR-mediated signaling in CLL samples resistant to idelalisib Preclinical in vivo investigations reveal favorable oral bioavailability across multiple species Early clinical findings suggest potential utility in CLL particularly in cases with ATM deletions or mutations

Catalog No. 50-000-89651