Apexbio Technology LLC CC-223 1228013-30-6 25mg

Supplier:  Apexbio Technology LLC B617125

CC-223 (CAS 1228013-30-6) is an orally bioavailable ATP-competitive inhibitor of mTOR kinase exhibiting potent activity with an IC50 of 16 nM It directly targets both mTORC1 and mTORC2 complexes effectively blocking downstream phosphorylation events including those mediated by 4EBP1 p70 S6 kinase and AKT CC-223 demonstrates high selectivity for mTOR over related kinases such as PI3K In preclinical studies CC-223 inhibited proliferation in various non-Hodgkin lymphoma and solid tumor cell lines including glioma breast hepatic and non-small cell lung cancers In vivo it produced dose- and schedule-dependent tumor growth inhibition in PC-3 xenograft models CC-223 has also shown tolerability and preliminary antitumor activity in early-phase clinical evaluations

Catalog No. 50-000-90881