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Medchemexpress LLC CCR2-RA-[R] | 512177-83-2 | 99.7% | 351.80 | 10 MG
SDP

Supplier:  Medchemexpress LLC 10MGHY50081

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CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2), inhibiting it non-competitively with an IC50 of 103 nM. It functions by blocking activation-associated conformational changes and the formation of the G protein-binding interface.

  • Binding pocket has balanced hydrophobic and polar features, favoring druggability
  • Displaces [125I]CCL2 from CCR2 with pIC50 of 6.1
  • pKD values for CCR2 and CCR5 are 8.8±0.1 and 7.0±0.1, respectively
  • Soluble in DMSO (37.5 mg/mL)
  • Stable as powder at -20°C for 3 years or 4°C for 2 years
  • Stable in solvent at -80°C for 2 years or -20°C for 1 year

Catalog No. 50-003-65655


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