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Apexbio Technology LLC CCT137690 1095382-05-0 10mg
Supplier: Apexbio Technology LLC A413210
CCT137690 (CAS 1095382-05-0) is an orally bioavailable small molecule inhibitor of aurora kinases targeting aurora A B and C with reported IC50 values between 15 and 25 nM Aurora kinases are serine/threonine kinases involved in the regulation of mitosis and are implicated in the progression of various cancers CCT137690 demonstrates potent inhibition of aurora kinase-mediated phosphorylation of histone H3 and suppresses proliferation in several cancer cell lines including ovarian and colorectal models with submicromolar IC50 values In vivo it slows tumor growth in xenograft models and sensitizes cells to radiotherapy CCT137690 is valuable for investigating aurora kinase function and chemoradiotherapeutic strategies in oncology research
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