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ABclonal Technology CD152/CTLA-4 Rabbit mAb
Supplier: ABclonal Technology A2286520UL
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells The protein contains a V domain a transmembrane domain and a cytoplasmic tail Alternate transcriptional splice variants encoding different isoforms have been characterized The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond while the soluble isoform functions as a monomer Mutations in this gene have been associated with insulin-dependent diabetes mellitus Graves disease Hashimoto thyroiditis celiac disease systemic lupus erythematosus thyroid-associated orbitopathy and other autoimmune diseases
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