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ABclonal Technology CD162/PSGL-1 Rabbit PolymAb
Supplier: ABclonal Technology A26626PM20UL
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes The inactive IL-18 precursor is processed to its active form by caspase-1 and is capable of stimulating interferon gamma production and of regulating both T helper (Th) 1 and Th2 responses This cytokine has been implicated in the injury of different organs and in potentially fatal conditions characterized by a cytokine storm In humans IL-18 gene is located on chromosome 11 Alternatively spliced transcript variants encoding different isoforms have been found for this gene
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