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ABclonal Technology CD239/BCAM Rabbit mAb
Supplier: ABclonal Technology A23758100UL
This gene encodes Lutheran blood group glycoprotein a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin The protein contains five extracellular immunoglobulin domains a single transmembrane domain and a short C-terminal cytoplasmic tail This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system Inactivating variants of this gene result in the recessive Lutheran null phenotype Lu(a-b-) of the Lutheran blood group Two transcript variants encoding different isoforms have been found for this gene
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