ABclonal Technology CD43 Rabbit mAb

Supplier:  ABclonal Technology A2591720UL

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells and is found on the surface of thymocytes T lymphocytes monocytes granulocytes and some B lymphocytes It contains a mucin-like extracellular domain a transmembrane region and a carboxy-terminal intracellular region The extracellular domain has a high proportion of serine and threonine residues allowing extensive O-glycosylation and has one potential N-glycosylation site while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals Different glycoforms of this protein have been described In stimulated immune cells proteolytic cleavage of the extracellular domain occurs in some cell types releasing a soluble extracellular fragment Defects in expression of this gene are associated with Wiskott-Aldrich syndrome

Catalog No. 50-000-12056