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Medchemexpress LLC CE-245677 10mg | 717899-97-3 | 98.14% | 513.38 | 10 MG
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Supplier:  Medchemexpress LLC HY11242310MG

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CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with cellular IC50s of 4.7 and 1 nM.

  • Potent reversible inhibitor of Tie2 and TrkA/B kinases.
  • Exhibits cellular IC50s of 4.7 nM for Tie2 and 1 nM for TrkA/B.
  • Shows >100x selectivity against various other angiogenic receptor tyrosine kinases, including KDR, PDGFR, and FGFR.
  • Demonstrates good oral absorption in in vivo rat PK studies with an oral bioavailability (F) of 80%.

Catalog No. 50-004-36377


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