Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC CE-245677 | 717899-97-3 | 98.1% | 513.38 | 100 MG
Supplier: Medchemexpress LLC HY112423100MG
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with cellular IC50s of 4.7 and 1 nM. It also demonstrates over 100x selectivity against other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, and FGFR. It shows good oral absorption in in vivo rat PK studies with a bioavailability of 80%.
- Potent reversible inhibitor of Tie2 and TrkA/B kinases.
- Cellular IC50s of 4.7 nM for Tie2 and 1 nM for TrkA/B.
- More than 100x selectivity against other angiogenic receptor tyrosine kinases (KDR, PDGFR, FGFR).
- Good oral absorption in in vivo rat PK studies (F=80%).
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?