Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000436729

Medchemexpress LLC CE-245677 | 717899-97-3 | 98.1% | 513.38 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY11242350MG

Encompass_Preferred

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with cellular IC50s of 4.7 nM and 1 nM, respectively. It exhibits >100x selectivity against other angiogenic receptor tyrosine kinases such as KDR, PDGFR, and FGFR.

  • Potent reversible inhibitor of Tie2 and TrkA/B kinases.
  • Cellular IC50s of 4.7 nM for Tie2 and 1 nM for TrkA/B.
  • High selectivity (>100x) against other angiogenic receptor tyrosine kinases (KDR, PDGFR, FGFR).
  • Shows good oral absorption in in vivo rat PK studies (F=80%).

Catalog No. 50-004-36729


May include imposed supplier surcharges.
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.