Cayman Chemical Celecoxib Inhibitors

Supplier:  Cayman Chemical 1000867250 MG

An NSAID and a COX-2 inhibitor (IC50 = 0.05 µM); selective for COX-2 over COX-1 (IC50 = 22.9 µM); induces apoptosis in BJAB and Jurkat cancer cells in a concentration-dependent manner; reduces blood glucose levels in a rat model of diabetes induced by STZ; reduces the latency to escape and the path length in the Morris water maze and also increases BDNF and TrkB protein levels in the hippocampus in the same model; inhibits production of IL-1β and TNF-α and reduces synovial fluid expression of the gene encoding MMP-3 in a rabbit model of osteoarthritis; increases serum levels of LDH, troponin-T, TNF-α, and CK-MB, markers of cardiotoxicity, in rats at 100 mg/kg per day

Catalog No. 50-289-0113