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Apexbio Technology LLC CEP-33779 1257704-57-6 50mg
Supplier: Apexbio Technology LLC A414650
CEP-33779 (CAS 1257704-57-6) is a highly selective orally active small-molecule inhibitor targeting Janus kinase 2 (JAK2) It demonstrates significant selectivity over other JAK family members with more than 40-fold selectivity over JAK1 and over 800-fold versus TYK2 In cellular assays such as the GeneBLAzer reporter system CEP-33779 effectively inhibits JAK2-mediated signaling in irf-bla TF-1 cells Preclinical studies indicate that CEP-33779 modulates immune responses associated with systemic lupus erythematosus and offers therapeutic benefit in animal models of lupus nephritis and rheumatoid arthritis Additionally it suppresses colorectal tumor growth by inhibiting IL-6/JAK2/STAT3 signaling supporting its utility in inflammation-driven cancer research
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