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Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 100 MG
Supplier: Medchemexpress LLC HY14949C100MG
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, exhibiting an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines.
- Oral, microtubule-active, antitumor compound
- Inhibits binding to tubulin
- Exhibits cytotoxicity in human tumor cell lines (IC50 of 18-40 nM)
- Effective against ovarian, breast, prostate, and cervical tumor cell lines
- Induces sub-G1 nuclei at low concentrations
- Causes G2-M block at concentrations above 50 nM
- Active against human tumor xenografts via i.v. and p.o. administration
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