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Medchemexpress LLC CFTR(inh)-172 | 307510-92-5 | 99.8% | 409.40 | 1 MG
Supplier: Medchemexpress LLC HY166711MG
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel. It reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. The inhibition is complete in approximately 10 minutes (t1/2=4 minutes) and is reversed after washout with a t1/2 of approximately 5 minutes. It is nontoxic to FRT cells after 24 hours at concentrations up to 100 μM. It reduces open probability by > 90% and significantly reduces cholera toxin-induced fluid secretion in mouse models.
- Potent and selective blocker of the CFTR chloride channel.
- Reversibly inhibits CFTR short-circuit current.
- Nontoxic to FRT cells at concentrations up to 100 μM.
- Reduces open probability of CFTR by > 90%.
- Reduces cholera toxin-induced fluid secretion in mouse models.
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