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Medchemexpress LLC Chenodeoxycholic acid sodium | 2646-38-0 | 98.6% | C24H39NaO4 | 1 G
Supplier: Medchemexpress LLC HY76847A1G
Chenodeoxycholic acid sodium is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. It inhibits 11 beta HSD2 with an IC50 of 22 mM and causes cortisol-dependent nuclear translocation, increasing transcriptional activity of the mineralocorticoid receptor (MR). This compound is for research use only.
- Inhibits 11 beta HSD2.
- Increases MR transcriptional activity.
- Stimulates Ishikawa cell growth via Cyclin D1 protein and mRNA expression.
- Activates TGR5-dependent pathway.
- Induces LDL receptor mRNA levels in Hep G2 cells.
- Increases HMG-CoA reductase and synthase mRNA levels.
- Activates C/EBPβ, enhancing luciferase gene transcription.
- Activates AMPK, leading to ERK1/2 activation.
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