Medchemexpress LLC CHIR-090 | 728865-23-4 | C24H27N3O5 | 50 MG

Supplier:  Medchemexpress LLC HY1546050MG

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to *E. coli* LpxC with a Ki of 4.0 nM. It acts as an antibiotic against *E. coli* and other Gram-negative pathogens. This compound also functions as a click chemistry reagent, containing an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.

• Potent, slow, tight-binding inhibitor of LpxC deacetylase
• Binds to *E. coli* LpxC with a Ki of 4.0 nM
• Click chemistry reagent containing an Alkyne group
• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Inhibits LpxC deacetylase from *Aquifex aeolicus*
• Exhibits antibiotic activity against *P. aeruginosa* and *E. coli*
• Inhibits LpxC orthologues from various Gram-negative pathogens at low nM levels

Catalog No. 50-003-76449