Eurofins Discoverx CHK2 (I157T), active, 250 µg. (14-741M)

Supplier:  Eurofins Discoverx 14741M

N-terminal GST and C-terminal 6xHis-tagged recombinant, human CHK2, amino acids 5-end, containing the I157T mutation. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. For detailed product information, visit www.discoverx.com/proteins.

Catalog No. 50-199-9270