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Medchemexpress LLC Chloroquine (standard) | 54-05-7 | 99.5% | 319.87 | 2 G
SDP

Supplier:  Medchemexpress LLC HY17589A2G

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Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. It functions as an autophagy and toll-like receptors (TLRs) inhibitor, and it has demonstrated high effectiveness in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).

  • Inhibits IL-12p70 release and reduces Th1-priming capacity.
  • Enhances IL-1-induced IL-23 secretion.
  • Suppresses MMP-9 mRNA expression.
  • Reduces HuH7 cell proliferation through TLR7 and TLR9 inhibition.
  • Potently blocks SARS-CoV-2 virus infection.
  • Blocks virus infection by increasing endosomal pH and interfering with receptor glycosylation.
  • Inhibits tumor growth in xenograft models.
  • Inhibits HCC development in rat models.

Catalog No. 50-003-87144


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