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Cayman Chemical CholIc ACD MaxSpec Stndard
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Supplier:  Cayman Chemical 31347100 UG

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A macrocyclic lactone immunosuppressant binds to FKBP12 (IC50 2 57 nM) inhibits proliferation of human PBMCs rat splenocytes and human coronary artery smooth muscle cells (IC50s 7 1337 and 0 8 nM respectively) has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s 1 2 and 1465 nM respectively) reduces symptom severity in a rat model of EAE (ED50 1 17 mg/kg per day) delays cardiac allograft rejection in rats (ED50 3 71 mg/kg per day) inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 Ug/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis

Catalog No. 50-299-2650


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