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Medchemexpress LLC Chroman 1 dihydrochloride | C24H30Cl2N4O4 | 5 MG
Supplier: Medchemexpress LLC HY15392A5MG
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, showing more potency against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK, with an IC50 of 150 nM. In vitro studies indicate that Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Inhibits MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
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