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Medchemexpress LLC CI-1040 (PD 184352) | 212631-79-3 | 99.9% | C17H14ClF2IN2O2 | 200 MG
Supplier: Medchemexpress LLC HY50295200MG
CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. It is intended for research use only, exhibiting potent MEK1 inhibition and minimal activity against related kinases. It completely inhibits mitogen-stimulated ERK phosphorylation in whole cells.
- Directly inhibits MEK1 with high specificity
- Induces apoptosis and inhibits proliferation
- Increases PUMA mRNA and protein levels
- Reduces adenoma formation in lung cancer models
- Decreases lung cell proliferation
- Shows antiproliferative activity in various cancer cell lines
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