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Apexbio Technology LLC Cilomilast 153259-65-5 200mg
Supplier: Apexbio Technology LLC A4329200
Cilomilast (CAS 153259-65-5) also known as SB-207499 or Ariflo is a second-generation phosphodiesterase-4 (PDE4) inhibitor By selectively inhibiting PDE4 the compound increases intracellular cAMP levels affecting signaling pathways that modulate inflammatory cell function and promote airway smooth muscle relaxation Cilomilast has been shown to suppress the release of pro-inflammatory mediators such as TNF- IL-8 and GM-CSF as well as reduce neutrophil infiltration and leukotriene B4 production It is primarily investigated for its anti-inflammatory properties in research related to chronic obstructive pulmonary disease (COPD) and other inflammatory airway disorders
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