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Medchemexpress LLC Cinpa1 | 102636-74-8 | 99.8% | 395.49 | 100 MG
Supplier: Medchemexpress LLC HY11024950MG
CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR). It reduces CAR-mediated transcription and can be used as a molecular tool for understanding CAR function.
- Inhibits CAR-mediated transactivation without activating PXR in HepG2 cells.
- Increases corepressor and reduces coactivator interaction with the CAR ligand-binding domain.
- Disrupts CAR binding to the promoter regions of target genes in chromatin immunoprecipitation assays.
- Efficiently inhibits CAR-LBD interaction with the coactivator peptide.
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