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Medchemexpress LLC Cinromide | 58473-74-8 | 99.83% | 1 ML
Supplier: Medchemexpress LLC HYB127410MM/1ML
Cinromide is an anticonvulsant agent that inhibits the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 of 0.5 μM. It is designed for research use only.
- Inhibits 5-HT-induced contractions in rat fundus strips by 46% (at 10-100 μM).
- Inhibits monoamine oxidase from rat liver and brain (at 100 μM).
- Demonstrates anticonvulsant effects against electroshock and leptazol-induced convulsions in mice.
- Shows a dose-related antileptazol activity in rats with an ED50 of 58 ± 11 mg/kg.
- Elevates the amount of leptazol needed to induce clonic seizures in rats.
- Depresses neuronal response to maxillary nerve stimuli, increasing latency and decreasing spike numbers.
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